The COVID-19 pandemic has demonstrated the devastating impact of a large-scale disease on global health and wellbeing, security and economies. It has also shown the importance of reliable preparedness systems, and international collaboration and co-ordination among diverse stakeholders. G20 leaders are actively encouraged to build on the lessons learned from the pandemic. These include: ensuring worldwide equitable access to tests, vaccines and treatments for COVID-19 and beyond; the importance of not leaving low and middle income countries (LMICs) behind; and ensuring resilient supply chains through new and more robust manufacturing policies and capacities.