In order to preserve the central role of the World Trade Organization (WTO) in global trade it is necessary to revive the negotiating function of the organization. Plurilateral cooperation can be a stepping stone towards closer integration on issues where multilateral consensus is not yet in sight. However, a closer analysis of older and current plurilaterals reveals that they are largely initiated by developed countries and are not a generally accepted negotiation method for all WTO members. This policy brief analyses plurilaterals on grounds of key criteria such as treatment of non-members, scope and membership. It then clarifies the key challenges of using plurilaterals as a negotiation approach to advance new sets of rules. The brief provides G20 and WTO members with a set of practical recommendations for the successful operation and conduct of plurilaterals to support a multilateral order that serves the interests of all members and, in particular, those of developing countries.